Case Study 6 Essay

1238 Words Jan 20th, 2015 5 Pages
Advanced Pathophysiology
Case Study 6

Case Study 6
Scenario: John is a 4 year-old boy who was admitted for chemotherapy following diagnosis of acute lymphoblastic leukemia (ALL). He had a white blood cell count of 250,000. Clinical presentation included loss of appetite, easily bruised, gum bleeding, and fatigue. Physical examination revealed marked splenomegaly, pale skin color, temperature of 102°F, and upper abdomen tenderness along with nonspecific arthralgia. Pathophysiology signs and symptoms
The primary pathophysiological etiology for signs, symptoms and laboratory findings in 4 year-old John’s case study are secondary splenomegaly as a result of primary Acute Lymphoblastic Leukemia (ALL). Because of its proximity to
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skin cells). The side effects of chemotherapy depend upon the type and dose of the agent given and the length of use. Common side effects might include: alopecia, stomatitis, and increased risk of infection (decreased white blood cells), thrombocytopenia, bruising, lethargy, anemia, anorexia, nausea, vomiting and diarrhea. Additionally, in a study by Gedaly-Duff et al., (2006), the authors surmised that sleep disturbances, pain and fatigue experienced by that of the pediatric patient, also affected the quality of life of the parents, as they often suffered similar symptoms throughout the course of child’s therapy. The most serious side effects of chemo for ALL, is the increased risk of acquiring acute myelogenous leukemia (AML), Non-Hodgkins lymphoma, and tumor lysis (Gallegos-Arreola et al., 2013).
Etiology and complications of ALL
Without chemotherapy intervention, ALL can lead to a decrease in red blood cell production (anemia). Additionally, due to the risk of developing neutropenia, the body’s natural immune response is compromised (Marchesi & Girardi, 2011). Reproductive infertility is also a risk of ALL due to the use of radiation and stem cell transplantation. Although rare, ALL patients are at risk for developing Richter’s Syndrome which is an aggressive chronic form of b-cell lymphocytic carcinoma. Subsequently, patients with chronic lymphocytic leukemia also are at risk for developing other types of

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